Direct Effect

Hyperthermia Cancer Institute- Los Angeles

The targeted heat delivered during hyperthermia treatments alone kills many cancer cells. Tumors are growing rapidly, and often their blood supply becomes insufficient for their size. Without proper blood supply, nutrients, oxygen and waste removal are limited. These factors have many implications for effective treatment strategies: Heat: When heat is applied to the body (during the hyperthermia treatment), tumors retain heat more than normal tissue because of the restricted blood flow. The heat can directly damage the tumor cellular membrane, nucleus and cell skeleton, causing tumor cellular death. Effect on pH: The restricted blood flow to tumors also affects waste removal. Increased waste, leads to higher acidity (Low pH). The application of heat through hyperthermia treatments increase anaerobic metabolites (waste), making the cell microenvironment toxic, thus destroying the tumor cell.