Publications

Molecular Effects of Hyperthermia on Cancer Cells

• Changes in fluidity/stability of cell membrane
• Changes in cell shape
• Impaired transmembrane transport
• Changes in membrane potential
• Modulation of transmembrane efflux pumps (MDR)
• Apoptosis induction
• Impairment of protein synthesis
• Protein denaturation
• Aggregation of proteins in the nuclear matrix
• Induction of HSP-synthesis
• Impairment of RNA/DNA synthesis
• Inhibition of repair enzymes
• Altered DNA conformation
• Other alterations of cell function
• Intracellular metabolism of other substrates

List of Key Publications About Hyperthermia

Wust, P., Hildebrandt, B., Sreenivasa, G., Rau, B., Gellermann, J., Riess, H., … Schlag, P. M. (2002). Hyperthermia in combined treatment of cancer. The Lancet. Oncology, 3(8), 487–497. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12147435

Jones, E. L., Oleson, J. R., Prosnitz, L. R., Samulski, T. V., Vujaskovic, Z., Yu, D., … Dewhirst, M. W. (2005). Randomized Trial of Hyperthermia and Radiation for Superficial Tumors. Journal of Clinical Oncology, 23(13), 3079–3085. https://doi.org/10.1200/JCO.2005.05.520

Hehr, T., Wust, P., Bamberg, M., & Budach, W. (2003). Current and Potential Role of Thermoradiotherapy for Solid Tumours. Oncology Research and Treatment, 26(3), 295–302. https://doi.org/10.1159/000071628

Falk, M. H., & Issels, R. D. (n.d.). Hyperthermia in oncology. International Journal of Hyperthermia : The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 17(1), 1–18. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11212876

van der Zee, J. (2002). Heating the patient: a promising approach? Annals of Oncology, 13(8), 1173–1184. https://doi.org/10.1093/annonc/mdf280

Cihoric, N., Tsikkinis, A., van Rhoon, G., Crezee, H., Aebersold, D. M., Bodis, S., … Ghadjar, P. (2015). Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry. International Journal of Hyperthermia, 31(6), 609–614. https://doi.org/10.3109/02656736.2015.1040471

Crezee, H., van Leeuwen, C. M., Oei, A. L., Stalpers, L. J. A., Bel, A., Franken, N. A., & Kok, H. P. (2016). Thermoradiotherapy planning: Integration in routine clinical practice. International Journal of Hyperthermia, 32(1), 41–49. https://doi.org/10.3109/02656736.2015.1110757

Kaur, P., Hurwitz, M. D., Krishnan, S., & Asea, A. (2011). Combined hyperthermia and radiotherapy for the treatment of cancer. Cancers, 3(4), 3799–3823. https://doi.org/10.3390/cancers3043799

Oei, A. L., Vriend, L. E. M., Crezee, J., Franken, N. A. P., & Krawczyk, P. M. (2015). Effects of hyperthermia on DNA repair pathways: One treatment to inhibit them all. Radiation Oncology, 10(1). https://doi.org/10.1186/s13014-015-0462-0

Phase III Clinical Evidence. (n.d.). Retrieved June 11, 2019, from https://pyrexar.com/clinical/clinical-trials
Jha, S., Sharma, P. K., & Malviya, R. (2016). Hyperthermia: Role and Risk Factor for Cancer Treatment. Achievements in the Life Sciences, 10(2), 161–167. https://doi.org/10.1016/J.ALS.2016.11.004

Skitzki, J. J., Repasky, E. A., & Evans, S. S. (2009). Hyperthermia as an immunotherapy strategy for cancer. Current Opinion in Investigational Drugs (London, England : 2000), 10(6), 550. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828267/

Peeken, J. C., Vaupel, P., & Combs, S. E. (2017). Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary? Frontiers in Oncology, 7, 132. https://doi.org/10.3389/fonc.2017.00132